منابع مشابه
Carcinogenicity of the anticancer topoisomerase inhibitor, amsacrine, in Wistar rats.
Amsacrine is an antineoplastic drug used in the treatment of acute adult leukemias. To assess its carcinogenic potential, groups of 50 male and 50 female rats were administered amsacrine by lateral tail vein injection at 0 (vehicle control), 0.25, 1, or 3 mg/kg once daily for 5 days, followed by a 23-day recovery period. This cycle of dosing and recovery was repeated a total of six times. The a...
متن کاملAlkaloids as anticancer agents
Alkaloids are a class of naturally occurring organic nitrogen containing bases. Typical alkaloids are derived from plant sources, they are basic, they contain one or more nitrogen atoms (usually in a heterocyclic ring) and they usually have a marked physiological action on man or other animals. Alkaloids have potent anticancer activity against various cancers. In this review mainly discussed ab...
متن کاملFlavonoids: promising anticancer agents.
Flavonoids are polyphenolic compounds that are ubiquitously in plants. They have been shown to possess a variety of biological activities at nontoxic concentrations in organisms. The role of dietary flavonoids in cancer prevention is widely discussed. Compelling data from laboratory studies, epidemiological investigations, and human clinical trials indicate that flavonoids have important effect...
متن کاملPreclinical toxicology of anticancer agents.
The use of animal toxicology as a potential predictive system for drug toxicity in man is particularly important to the field of cancer chemotherapy because of several major clinical considerations (11). The nature of the growth characteristics of tumors in man requires that repeated courses of treatment be given oven extended periods of time; this approach carries with it an increased risk for...
متن کاملRadiation Recall with Anticancer Agents
Radiation recall is an acute inflammatory reaction confined to previously irradiated areas that can be triggered when chemotherapy agents are administered after radiotherapy. It remains a poorly understood phenomenon, but increased awareness may aid early diagnosis and appropriate management. A diverse range of drugs used in the treatment of cancer has been associated with radiation recall. As ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1991
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.16.supplementii_27